Clinical, pathological and molecular prognostic factors in colorectal cancer

Abstract

While histopathologic assessment of lymph nodes is a core element of colorectal cancer staging algorithms, the prognostic value of lymph node metastases is restricted. This highlights the need for approaches that detect occult tumor cells and define their prognostic value, to identify colorectal cancer patients who derive the greatest benefit from therapy. In an attempt to gain insights into prognosis in CRC, this thesis focuses on factors that play a role in the detection or behaviour of occult tumor cells. Especially clinical, pathological and molecular factors of CRC will here be discussed.