Unraveling mechanisms of vascular remodeling in arteriovenous fistulas for hemodialysis

Author(s):
Wong, C.Y.
Published
2017
Publication type
Doctoral Thesis

Abstract

Hemodialysis is the most widely used option in chronic dialysis treatment and requires a suitable vascular access. Unfortunately, this vascular

access suffers from a high number of failures responsible for a high morbidity and health care costs. However, the exact pathophysiology remains unclear. In order to unravel the mechanisms of arteriovenous fistula failure we developed a novel murine model of arteriovenous fistula failure. Using this model, we studied the effects of vascular remodeling in mice that were haplodeficient for the eln gene. The role of inflammation in arteriovenous remodeling was also investigated by administrating liposomal prednisolone and by incorporating RP105 knockout mice.

Arteriovenous fistulaAnimal modelHemodialysisAnastomosisMicrosurgeryLiposomal prednisoloneRP105
Defense date
2017-03-08
Language
English
Supervisor(s)
Rabelink, A.J.; Quax, P.H.A.
Advisor(s)
Rotmans, J.I.
Committee member(s)
Bogt, K.E.A. van der; Verhagen, H.J.M.; Vries, C.J.M. de; Hamming, J.F.
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/46406
ISBN(s)
9789492332189

Funding

Sponsorship
Nederlandse hartstichting, Krijnen medical, Alrijne zorggroep, Astellas Pharma, Fresenius Medical Care, Enceladus Pharmaceuticals en Chipsoft