A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations

Author(s):
Yamamoto, Y.; Välitalo, P.A.; Berg, D.J. van den; Hartman, R.J. (0000-0002-3078-3814); Brink, W. van den; Wong, Y.C. (0000-0002-8577-3277); Huntjens, D.R.; Proost, J.H.; Vermeulen, A.; Krauwinkel, W.; Bakshi, S.D.; Aranzana-Climent, V.; Marchand, S.; Dahyot-Fizelier, C.; Couet, W.; Danhof, M. (0000-0002-2319-6830); Hasselt, J.G.C. van (0000-0002-1664-7314); Lange, E.C.M. de (0000-0001-8303-1117)
Published
2016
Publication type
Article / Letter to editor
blood-brain barriercentral nervous system (CNS)human predictionpharmacokineticstranslational model
Date issued
2016-11-18
Language
English
Is part of
Pharmaceutical Research (2016), Vol. 34, no. 2, p. 333–351
hdl
1887/45949
doi
10.1007/s11095-016-2065-3