Growth, endocrine function and quality of life after haematopoietic stem cell transplantation

Author(s):
Bakker, B.
Published
2006
Publication type
Doctoral Thesis

Abstract

This thesis contains the results of several studies on the long-term consequences of the myeloablative conditioning for haematopoietic stem cell transplantation (SCT) during infancy and childhood, with the emphasis on late effects on endocrine functions. After a general introduction, effects of total-body irradiation (TBI) on pituitary and thyroid glands in rhesus monkeys and effects of irradiation on growth plates in growing rats are discussed. After these experimental animal data, effects of different conditioning regimens for SCT in children on growth, pubertal development, thyroid function and quality of life are discussed in subsequent chapters, and results of growth hormone therapy in these patients are presented. All study results presented in the thesis and relevant data from the literature are integrated into a general discussion at the end of the thesis.

Haematopoietic stem cell transplantationQuality of lifeGonadal functionTotal-body irradiationLongitudinal growth growth hormone secretionGrowth hormone secretionThyroid functionPubertal developmentFertility
Defense date
2006-04-27
Language
English
Supervisor(s)
Wit, J.M.; Vossen, J.M.J.J.
Advisor(s)
Oostdijk, W.
Qualification
Ph.D.
Degree granting institution
Department of Paediatrics, Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
Publisher
Wageningen: Ponsen & Looijen b.v.
hdl
1887/4375
ISBN(s)
9789090203362

Juridical information

Court
LEI Universiteit Leiden

Funding

Sponsorship
The Research presented in this thesis was financially supported by the Netherlands’ Orginazation for Scientific Research (NWO / ZonMw). For publication of this thesis, financial support from Ferring Geneesmiddelen B.V., Ipsen Farmaceutica B.V., Novo Nordisk Farma B.V., Pfizer B.V., Eli Lilly Nederland B.V. and ZonMw is gratefully acknowledged.