Diagnostics and treatment options in low-grade central chondrosarcomas

Abstract

The first part of my thesis concerns a multicenter study in nine different European countries of patients with one of the rare diseases Ollier disease or Maffucci syndrome. We collected clinical data to look to factors that predict prognosis and chance to develop secondary chondrosarcoma.

In the second part of this thesis describes different aspects in the intralesional treatment of low-grade chondrosarcoma of long bones. In our series, we used phenol as an adjuvant therapy. First, the cell-killing effect of phenol was investigated. Also, clinical parts of the surgery were studied. We described a patients series of patients treated this way. Also, we looked to the postoperative characteristics on Gd-MRI.