Persistent URL of this record https://hdl.handle.net/1887/43472
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The skin as a mirror of the aging process
This thesis describes to which extent the skin reflects the aging process, with a specific focus on cellular senescence. Since the first descriptions of the growth arrested state of fibroblasts upon multiple replication rounds, cellular senescence has now emerged as a promising target to regulate the aging process in vivo as well. Here, we study whether fibroblast senescence in vitro is associated with in vivo donor characteristics such as chronological age and prevalence of disease. We further describe in this thesis whether senescence in skin tissue (in situ) is associated with other histological skin characteristics and with in vivo donor characteristics.
- All authors
- Waaijer, M.E.C.
- Supervisor
- Westendorp, R.G.J.; Maier, A.B.
- Committee
- Tanke, H.J.; Boomsma, D.I.; Demaria, M.
- Qualification
- Doctor (dr.)
- Awarding Institution
- Medicine , Leiden University
- Date
- 2016-10-12
- ISBN (print)
- 9789462333826
Funding
- Sponsorship
- Unilever PLC; Alrijne Zorggroep; Nederlandse Vereniging voor Gerontologie