Direct-to-treatment MRI-guided prostate radiotherapy using a generic patient-agnostic reference plan

Author(s):
Tsekas, G.; Wiersema, L.; Conijn, S.; Sundaram, J.; Heide, U.A. van der; Janssen, T.
Published
2026
Publication type
Article / Letter to editor

Abstract

Background: Background and Purpose: Offline plan preparation is a time-consuming step in MRI-guided radiotherapy (MRIgRT). This work explores the use of a patient-agnostic reference plan and delineations for direct-to-treatment (DtT) MRI-guided prostate RT, without any patient-specific treatment preparations.

Material and Methods: The data of ten prostate cancer patients were used to simulate a (DtT) workflow: During fraction 1, patient-specific contour adaptations were performed and a treatment plan was created, which was used for the rest of the fractions. The DtT treatment plans were evaluated against the clinical RT plans using the clinical delineations.

Results: All DtT plans reached sufficient PTV coverage (V-3444cGy > 99%), while resulting in comparable OAR dose distributions to the clinical plans. Conclusion: Our DtT workflow resulted in adequate PTV coverage at the cost of small increase to the dose of some organs-at-risk and a high overall efficiency gain.

Direct-to-treatmentProstate radiotherapyMR-linacAdaptive radiotherapy
Date issued
2026-03-01
Language
English
Publisher
ELSEVIER
Is part of
Technical Innovations and Patient Support in Radiation Oncology
hdl
1887/4310388
doi
10.1016/j.tipsro.2025.100370