Plasmodium falciparum and Necator americanus in Gabon: observation, intervention, and controlled human infection
Abstract
This thesis, conducted in Lambaréné, Gabon, examines malaria and hookworm as major parasitic diseases that continue to burden low-resource settings. The thesis highlights the need for improved point-of-care biomarkers, assesses the PfSPZ malaria vaccine, and establishes a controlled human hookworm infection model in a hookworm endemic area for the first time. The effect of pre-exposure to malaria or hookworm infection on the human immune response is an important theme.
Acute febrile illnessAntimicrobial stewardshipMalariaHookwormControlled human infection modelPlasmodium falciparumNecator americanusVaccine developmentThe NetherlandsGabon
