Discovering biomarkers and druggable targets in uveal melanoma

Author(s):
Wierenga, A.P.A. (0000-0002-3537-3662)
Published
2026
Publication type
Doctoral Thesis

Abstract

This thesis describes several projects on the subject of uveal melanoma. There are good treatment options for the primary tumor in the eye, but around half of the patients develop metastases. There is no cure for these metastases yet. The projects described in thesis aim to identify biomarkers as potential druggable targets. Also it focused on the role of iris pigmentation and tumor pigmentation and the tumor characteristics of these tumors.

Uveal melanomaMetastatic uveal melanomaLiquid biopsiesBiomarkersAqueous humorCytokinesImmunotherapy
Defense date
2026-06-24
Language
English
Supervisor(s)
Jager, M.J.; Luyten, G.P.M.
Advisor(s)
Verdijk, R.
Committee member(s)
Schalij-Delfos, N.E.; Naus, N.D.; Heindl, L.M.; Snaar-Jagalska, E.; Piperno-Neumann, S.
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/4306948
doi
10.60602/1887-4306948
ISBN(s)
9789465376035