DNA sequencing using biological nanopores has revolutionized our understanding of diseases and genetics. However, their instability in harsh chemical environments limits their applicability for analysing other biomolecules, such as proteins. My thesis focuses on graphene nanopores as a suitable alternative platform. Graphene is a material only one atom thick, which makes it ideal for achieving high accuracy sequencing of molecules.
To develop viable graphene nanopores for sequencing technology, I have investigated two main aspects. First, I have developed molecular tweezers that can bind the edges of graphene nanopores. By fundamentally understanding the interaction between molecular tweezers and graphene edges, we can precisely control the chemistry of graphene nanopores. Second, I have developed an efficient and scalable method for graphene nanopore fabrication using a controlled breakdown technique.
This thesis bridges the gap between...
Show moreDNA sequencing using biological nanopores has revolutionized our understanding of diseases and genetics. However, their instability in harsh chemical environments limits their applicability for analysing other biomolecules, such as proteins. My thesis focuses on graphene nanopores as a suitable alternative platform. Graphene is a material only one atom thick, which makes it ideal for achieving high accuracy sequencing of molecules.
To develop viable graphene nanopores for sequencing technology, I have investigated two main aspects. First, I have developed molecular tweezers that can bind the edges of graphene nanopores. By fundamentally understanding the interaction between molecular tweezers and graphene edges, we can precisely control the chemistry of graphene nanopores. Second, I have developed an efficient and scalable method for graphene nanopore fabrication using a controlled breakdown technique.
This thesis bridges the gap between fundamental supramolecular chemistry and practical applications in nanotechnology. By simplifying fabrication methods and understanding chemical interactions, I have provided the foundation for the development of faster, more accurate diagnostic tools that can analyse a broader range of biomolecules.
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