Neo-adjuvant VEGF inhibition in STS: investigating the role of neo-adjuvant pazopanib and radiotherapy for localized soft tissue sarcoma

Author(s):
Meekeren, M. van (0000-0001-6934-8652)
Published
2026
Publication type
Doctoral Thesis

Abstract

In this doctoral thesis, the neo-adjuvant combination of pazopanib and radiotherapy was assessed in localized, high-risk soft tissue sarcoma. Clinical outcomes, as well as imaging and pharmacokinetic biomarker approaches were reported

Soft tissue sarcomaNeo-adjuvant radiotherapyPazopanibImaging biomarkersIntra-tumoral drug concentrations
Defense date
2026-05-28
Language
English
Supervisor(s)
Haas, R.L.M.
Advisor(s)
Gelderblom, H.; Fiocco, M.
Committee member(s)
Sande, M.A.J. van de; Bovée, J.V.M.G.; Graaf, W.T.A. van der; Wiltink, L.M.; Schrage, Y.M.
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/4304960
doi
10.60602/1887-4304960