Combining surgery and systemic therapy in metastatic melanoma

Author(s):
Blankenstein, S.A.M.
Published
2026
Publication type
Doctoral Thesis

Abstract

The main focus of this thesis is investigating the combination of surgery and systemic therapy to enhance melanoma treatment. Studies described in the thesis show systemic therapy paving the way for surgery in unresectable disease or to reduce recurrences after surgery, as well as surgery aiding systemic therapy after initial disease control.

Metastatic melanomaSurgeryTargeted therapyImmunotherapyImmune checkpoint inhibitors
Defense date
2026-04-30
Language
English
Supervisor(s)
Haanen, J.B.A.G.
Advisor(s)
Akkooi, A.C.J. van
Committee member(s)
Wouters, M.W.J.M; Kapiteijn, H.W.; Hoeven, J.J.M. van der; Verhoef, C.; Hospers G.A.P.
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/4303011
ISBN(s)
9789465370125