Synthetic peptides and small molecules as tools to investigate Ubiquitin and Ubiquitin-like modifications

Author(s):
Scherpe, S. (0000-0003-0532-5229)
Published
2026
Publication type
Doctoral Thesis

Abstract

Investigating the ubiquitin system with synthetic peptides and small molecules to further our understanding of its function in cells, as well as its role in the development of diseases, such as cancer.

UbiquitinSolid-phase peptide synthesis (SPPS)In-cell NMRActivity-based probe (ABP)High-throughput screeningSmall molecule inhibitorDeubiquitinase (DUB)SENP1USP32
Defense date
2026-04-08
Language
English
Supervisor(s)
Ovaa, H.; Neefjes, J.J.C.
Advisor(s)
Sapmaz, A.; Mulder, M.P.C.
Committee member(s)
Vertegaal, A.C.O.; Heitman, L.H.; Folkers, G.E.; Stelt, M. van der; Heden van Noort, G.J. van der
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/4301070
doi
10.60602/1887-4301070
ISBN(s)
9789465342122