From labelled to the optimal clinical dose: model-informed dose optimization in medical oncology practice

Tan, Z. (2026)

Doctoral Thesis

In this PhD thesis, available data on the PK and/or PD of different targeted therapies, chemotherapy and immunotherapies obtained during both routine clinical practice and prospective clinical studies were analyzed. The primary aim of this project was to optimize oncology drug treatment by analyzing available pharmacokinetic and pharmacodynamic data from patients treated with these therapies using different modeling and simulation approaches. Ultimately these efforts may lead to optimized and individualized cancer treatment with optimal efficacy, reduced toxicity and less drug expenses.

• All authors: Tan, Z.
• Supervisor: Knibbe, C.A.J.
• Co-supervisor: Moes, D.J.A.R.; Völler, S.
• Committee: Eck, M. van; Lange, E.C.M. de; Erp, N.P. van; Gelder, T. van; Hasselt, J.G.C. van; Koolen, S.L.W.
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University
• Date: 2026-03-31
• ISBN (print): 9789465342412