Simulation-based assessment of the P-glycoprotein expression-activity relationship shows a drug and system dependency

Author(s):: Valkengoed, D.W. van (0009-0006-7830-2553); Rottschäfer V.; Lange E.C.M. de

Published: 2026
Publication type: Article / Letter to editor

P-glycoproteinIVIVEExpression-activityBBBKinetic modelling

Date issued: 2026-02-02
Language: English
Publisher: Springer Science and Business Media LLC
Is part of: Journal of Pharmacokinetics and Pharmacodynamics (2026), 10
hdl: 1887/4299323
doi: 10.1007/s10928-025-10015-6
URL: https://link.springer.com/article/10.1007/s10928-025-10015-6

Funding

Sponsorship: Horizon 2020(H2020)
Grant number: 848068