Simulation-based assessment of the P-glycoprotein expression-activity relationship shows a drug and system dependency

Valkengoed, D.W. van; Rottschäfer V.; Lange E.C.M. de (2026)

Article / Letter to editor

• P-glycoprotein
• IVIVE
• Expression-activity
• BBB
• Kinetic modelling

• All authors: Valkengoed, D.W. van; Rottschäfer V.; Lange E.C.M. de
• Date: 2026-02-02
• Journal: Journal of Pharmacokinetics and Pharmacodynamics
• Volume: 53
• DOI: doi:10.1007/s10928-025-10015-6
• Link: https://link.springer.com/article/10.1007/s10928-025-10015-6
• Sponsorship: Horizon 2020(H2020)
• Grant number: 848068