Helminths target macrophage epigenetics and metabolism to evade immunity

Author(s):
Everts, B.
Published
2025
Publication type
Article / Letter to editor

Abstract

Parasitic helminths are well known master regulators of host immune responses. Yet, the underlying molecular principles remain largely enigmatic. Recent work from Bohnacker et al. reveals that glutamate dehydrogenase (GDH), a metabolic enzyme secreted by Heligmosomoides polygyrus, can suppress type 2 immunity by multi modal regulation of macrophage metabolism and epigenetics.

Date issued
2025-03-05
Language
English
Publisher
CELL PRESS
Is part of
Trends in Parasitology (2025), Vol. 41, no. 3, p. 172-174
hdl
1887/4298206
doi
10.1016/j.pt.2025.01.012

Funding

Sponsorship
NWO
Grant number
91719349