Clinical features and outcomes of bullous central serous chorioretinopathy: a multicentric cohort study

Author(s):
Montesel, A.; Sacconi, R.; Nicholson, L.; Chhablani, J.; Yzer, S.; Mohabati, D.; Boon, C.J.F.; Querques, G.
Published
2025
Publication type
Article / Letter to editor

Abstract

Introduction: The bullous variant of central serous chorioretinopathy (bvCSC) represents a rare and severe manifestation of CSC. This study aims to evaluate the clinical features, underlying systemic factors, and outcomes of bvCSC through a multicentric study.

Methods: A retrospective analysis was conducted on patients diagnosed with bvCSC across five tertiary eye centers. Demographic data, visual acuity (VA), treatment modalities, and follow-up outcomes were analyzed. A literature review was performed to contextualize the findings.

Results: The study included 35 eyes from 25 patients (80% male), with a mean age of 47.7 +/- 12.2 years. Systemic comorbidities were identified in 60% of patients. Baseline VA was 1.18 +/- 0.89 logMAR. Serous retinal detachment resolved in 63% of eyes, but persistent subretinal fibrosis contributed to limited visual recovery. Treatment varied, with observation (37%) being the most common approach, followed by systemic eplerenone (17%) and focal laser (13%). Available data did not show a clear advantage of any treatment modality. Conclusion: The bvCSC is frequently associated with systemic conditions and has a guarded visual prognosis despite anatomical resolution in most cases. The study underscores the importance of early diagnosis and a tailored treatment to optimize outcomes in this severe CSC variant.

Bullous variantCentral serous chorioretinopathyMulticentricClinical featuresVisual outcomesTreatmentReview
Date issued
2025-11-21
Language
English
Publisher
KARGER
Is part of
Ophthalmologica: The European Retina Journal (2025), Vol. 249, no. 1, p. 41-49
hdl
1887/4298142
doi
10.1159/000549637