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Reibel-Georgi, N.J.; Scrivens, A.; Heeger, L.E.; Lopriore, E.; New, H.; Deschmann, E.; ... ; Dame, C. (2025)

Supplemental iron and recombinant erythropoietin for anemia in infants born very preterm: a survey of clinical practice in Europe

Article / Letter to editor
ObjectivesTo survey practices of iron and recombinant human erythropoietin (rhEpo) administration to infants born preterm across Europe.Study designOver a 3-month period, we conducted an online survey in 597 neonatal intensive care units (NICUs) of 18 European countries treating infants born with a gestational age of <32 weeks.ResultsWe included 343 NICUs (response rate 56.3%) in the survey. Almost all NICUs (97.7%) routinely supplement enteral iron, and 74.3% of respondents to all infants born <32 weeks of gestation. We found that 65.3% of NICUs routinely evaluate erythropoiesis and iron parameters beyond day 28 after birth. Most NICUs initiate iron supplementation at postnatal age of 2 weeks and stop after 6 months (34.3%) or 12 months (34.3%). Routine use of rhEpo was reported in 22.2% of NICUs, and in individual cases in 6.9%. RhEpo was mostly administered subcutaneously (70.1%) and most frequently at a dose of 250 U/kg 3...Show moreObjectivesTo survey practices of iron and recombinant human erythropoietin (rhEpo) administration to infants born preterm across Europe.Study designOver a 3-month period, we conducted an online survey in 597 neonatal intensive care units (NICUs) of 18 European countries treating infants born with a gestational age of <32 weeks.ResultsWe included 343 NICUs (response rate 56.3%) in the survey. Almost all NICUs (97.7%) routinely supplement enteral iron, and 74.3% of respondents to all infants born <32 weeks of gestation. We found that 65.3% of NICUs routinely evaluate erythropoiesis and iron parameters beyond day 28 after birth. Most NICUs initiate iron supplementation at postnatal age of 2 weeks and stop after 6 months (34.3%) or 12 months (34.3%). Routine use of rhEpo was reported in 22.2% of NICUs, and in individual cases in 6.9%. RhEpo was mostly administered subcutaneously (70.1%) and most frequently at a dose of 250 U/kg 3 times a week (44.3%), but the dose varied greatly between centers.ConclusionsThis survey highlights wide heterogeneity in evaluating erythropoietic activity and iron deficiency in infants born preterm. Variation in iron supplementation during infancy likely reflects an inadequate evidence base. Current evidence on the efficacy and safety profile of rhEpo is only poorly translated into clinical practice. This survey demonstrates a need for standards to optimize patient blood management in anemia of prematurity.Show less
All authors
Reibel-Georgi, N.J.; Scrivens, A.; Heeger, L.E.; Lopriore, E.; New, H.; Deschmann, E.; Stanworth, S.J.; Carrascosa, M.A.; Braekke, K.; Cardona, F.; Cools, F.; Farrugia, R.; Ghirardello, S.; Krivec, J.L.; Matasova, K.; Muehlbacher, T.; Sankilampi, U.; Soares, H.; Szabo, M.; Szczapa, T.; Zaharie, G.; Christoph, C.; Fustolo-Gunnink, S.; Dame, C.
Date
2025-01-31
Journal
The Journal of Pediatrics
Volume
276
DOI
doi:10.1016/j.jpeds.2024.114302