The use of 3D skin equivalents mimicking skin cancers: unraveling the heterogeneity of cancer-associated fibroblasts and validating therapeutic efficacy

Author(s):
Wu, S.
Published
2026
Publication type
Doctoral Thesis

Abstract

The work presented in this thesis demonstrated multidisciplinary cooperation among Oncology, Bioengineering, Nanomedicine, and Pharmacology. This thesis aims to elucidate aspects of CAF heterogeneity using 3D FTMs that mimic different types of skin (epithelial) cancers, and to examine the potential of 3D FTMs for drug efficacy evaluation, with a particular focus on tumor-stroma interactions.

Human Skin EquivalentCancer-associated fibroblastSkin cancerPathway inhibitorsTumor invasion
Defense date
2026-03-12
Language
English
Supervisor(s)
Vermeer, M.H.
Advisor(s)
El Ghalbzouri, A.
Committee member(s)
Doorn, R. van; Dijke, P. ten; Maaden, K. van der; Keizer, P.L.J. de; Snaar-Jagalska, B.E.
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/4296712
doi
10.60602/1887-4296712
ISBN(s)
9789465341828