Novel strategies targeting lipid metabolism to combat sepsis

Author(s):
Li, M. (0000-0002-5472-3699)
Published
2026
Publication type
Doctoral Thesis

Abstract

Sepsis remains a leading cause of mortality worldwide, yet effective targeted therapies beyond supportive care are lacking. This thesis explores novel therapeutic strategies centered on lipid metabolism to improve outcomes in sepsis, integrating large-scale clinical data, genetic approaches, and mechanistic animal studies.

SepsisLipid metabolismHigh-density lipoprotein (HDL)CETP inhibitionStatinsHydrocortisoneMendelian randomizationBrown adipose tissue
Defense date
2026-03-03
Language
English
Supervisor(s)
Rensen, P.C.N.
Advisor(s)
Kooijman, S.; Noordam, R.
Committee member(s)
Cannegieter, S.; Winther, M.P.J. de; Bouma, H.R.; Roestenberg, M.
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/4295014
doi
10.60602/1887-4295014
ISBN(s)
9789465372181