Exploring kidney organoid vascularization

Author(s):
Koning, M. (0000-0001-9094-1004)
Published
2026
Publication type
Doctoral Thesis

Abstract

Kidney organoids generated from human induced pluripotent stem cells resemble human kidney tissue to a certain degree. However, they lack a functional vasculature and remain immature. This thesis explores the process of kidney organoid vascularization and its effect on organoid development and maturation.

KidneyOrganoidInduced pluripotent stem cellsEndothelial cellsVascularization
Defense date
2026-02-04
Language
English
Supervisor(s)
Rabelink, A.J.
Advisor(s)
Berg, C.W. van den
Committee member(s)
Geijsen, N.; Peters, D.J.M.; Orlova, V.; Jaffredo, T.; Carmeliet, P.
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/4288745
doi
10.60602/1887-4288745
ISBN(s)
9789465229782