Analysis of sequential treatments for hematological diseases by advanced statistical methods

Koster, E.A.S. (2026)

Doctoral Thesis

In this thesis we investigated how analysis of specific clinical settings and application of advanced statistical methodology on high-quality observational data can be used to investigate complex research questions in the field of hematology. We studied two clinical settings: allogeneic hematopoietic stem cell transplantation for patients with acute leukemia and immunosuppressive therapy for patients with acquired aplastic anemia. By applying multi-state and joint models on detailed observational data we could capture complex recovery and failure patterns and their underlying mechanisms.

• Allogeneic hematopoietic stem cell transplantation
• Donor lymphocyte infusion
• T-cell depletion
• Graft-versus-Host-Disease
• Graft-versus-Leukemia effect
• Aplastic anemia
• Multi-state model
• Joint model

• All authors: Koster, E.A.S.
• Supervisor: Falkenburg, J.H.F.
• Co-supervisor: Halkes, C.J.M.; Wreede, L.C. de
• Committee: Putter, H.; Lankester, A.C.; Hazenberg, M.D.; Versluis, J.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2026-02-03
• ISBN (print): 9789465370774
• Sponsorship: The research of this thesis was financially supported by the Landkroon fellowship from the Doelfonds Leukemie of the Bontius Stichting.