Analysis of sequential treatments for hematological diseases by advanced statistical methods

Author(s):
Koster, E.A.S. (0000-0002-8446-5133)
Published
2026
Publication type
Doctoral Thesis

Abstract

In this thesis we investigated how analysis of specific clinical settings and application of advanced statistical methodology on high-quality observational data can be used to investigate complex research questions in the field of hematology. We studied two clinical settings: allogeneic hematopoietic stem cell transplantation for patients with acute leukemia and immunosuppressive therapy for patients with acquired aplastic anemia. By applying multi-state and joint models on detailed observational data we could capture complex recovery and failure patterns and their underlying mechanisms.

Allogeneic hematopoietic stem cell transplantationDonor lymphocyte infusionT-cell depletionGraft-versus-Host-DiseaseGraft-versus-Leukemia effectAplastic anemiaMulti-state modelJoint model
Defense date
2026-02-03
Language
English
Supervisor(s)
Falkenburg, J.H.F.
Advisor(s)
Halkes, C.J.M.; Wreede, L.C. de
Committee member(s)
Putter, H.; Lankester, A.C.; Hazenberg, M.D.; Versluis, J.
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/4288690
doi
10.60602/1887-4288690
ISBN(s)
9789465370774

Funding

Sponsorship
The research of this thesis was financially supported by the Landkroon fellowship from the Doelfonds Leukemie of the Bontius Stichting.