Substrates and inhibitors to study and modulate ER-I α-glucosidase activity

Author(s):
Heming, J.J.A. (0000-0002-9217-3616)
Published
2026
Publication type
Doctoral Thesis

Abstract

This thesis describes research aimed at discovering inhibitors selective for either of the two endoplasmic reticulum α-glucosidases, ER-I and ER-II, with the overarching goal of discovering new antiviral agents to treat viruses that rely on host N-glycosylation for proliferation. It also describes assays that measure the activity of these enzymes and the effects of inhibitors on them.

Defense date
2026-01-16
Language
English
Supervisor(s)
Overkleeft, H.S.; Artola, M.E.
Committee member(s)
Ubbink, M.; Kasteren, S.I. van; Codée, J.D.C.; Boltje, T.J.; Willems, L.I.
Qualification
Ph.D.
Degree granting institution
Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University, Leiden
hdl
1887/4286864
doi
10.60602/1887-4286864
ISBN(s)
9789464739824