Exploring the chemicals space of Paenibacillus NRPs and discovery of Paenilipoheptin B

Author(s):
Machushynets, N.V. (0000-0002-8530-1966); Lysenko, V.; Du, C. (0000-0003-3447-5293); Slingerland, C.J.; Elsayed, S.S. (0000-0003-3837-6137); Liles, M.R.; Martin, N.I. (0000-0001-8246-3006); Wezel, G.P. van (0000-0003-0341-1561)
Published
2025
Publication type
Article / Letter to editor

Abstract

A combination of genomic and metabolomic analyses paired with molecular networking was applied to a collection of Paenibacillus spp. to identify the producers of a little-studied class of lipopeptides known as paenilipoheptins. Mass spectrometry and NMR spectroscopy allowed revision of the structure of previously reported paenilipoheptin A and elucidation of the structure of novel paenilipoheptin B.

Date issued
2025-03-28
Language
English
Is part of
Organic Letters (2025), Vol. 27, no. 12, p. 2821-2825
hdl
1887/4285890
doi
10.1021/acs.orglett.5c00231
URL
https://pubs.acs.org/doi/10.1021/acs.orglett.5c00231