Risk assessment tools and adjuvant therapy for breast cancer

Noordhoek, I. (2025)

Doctoral Thesis

Breast cancer is the most common cancer in women. Several prognostic and predictive models have been developed to improve tailoring of adjuvant treatment to the individual patient. This thesis aimed to provide guidance in navigating different risk assessment tools. Once we are able to accurately assign to their risk group, we can optimize and personalize adjuvant treatment strategies.

• Prognostic model
• Predictive model
• Hormone receptor positive breast cancer
• Extended endocrine therapy
• Bisphosphonate treatment

• All authors: Noordhoek, I.
• Supervisor: Portielje, J.E.A.; Liefers, G.J.
• Co-supervisor: Kroep, J.R.
• Committee: Linn, S.C.; Vrancken-Peeters, M.J.T.F.D.; Gelderblom, A.J.; Hage, J.A. van der; Wesseling, J.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2025-12-10