Immunity against post-translationally modified proteins in autoimmune diseases

Author(s):
Beukel, M.D. van den
Published
2025
Publication type
Doctoral Thesis

Abstract

In this thesis immunity against post-translationally modified proteins was investigated. Antibodies targeting PTMs were investigated in three patient cohorts (RA, SLE and AILD) and associations with clinical markers explored. Furthermore, we observed that the complement system was activated on several PTMs contributing to the understanding of immunity against PTMs in autoimmunity.

Post-translational modificationRheumatoid ArthritisComplement systemImmunityAutoimmunityAutoantibodiesAutoimmune disease
Defense date
2025-11-18
Language
English
Supervisor(s)
Trouw, L.A.; Parren, P.W.H.I.
Committee member(s)
Kooten, C. van; Kasteren, S.I. van; Woude, D. van der; Rooijakkers, S.H.M.; Vidarsson, G.
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/4283341
ISBN(s)
9789464964882

Funding

Sponsorship
European Research Council (ERC), grant to support PhD trajectory. Hycult contributed to the printing of the thesis.