The impact of drug properties and severity of obesity on renal drug clearance through glomerular filtration and active tubular secretion: a systematic analysis using PBPK modeling

Author(s):
Zhang, T. (0000-0001-9355-2370); Calvier, E.A.M.; Krekels, E.H.J. (0000-0001-6006-1567); Knibbe, C.A.J. (0000-0001-9893-4415)
Published
2025
Publication type
Article / Letter to editor
allometric scalingclearance scalingobesityPBPK modelingrenal transporter activity
Date issued
2025-06-27
Language
English
Publisher
Springer Science and Business Media LLC
Is part of
Pharmaceutical Research (2025), Vol. 42, p. 1079-1088
hdl
1887/4282843
doi
10.1007/s11095-025-03885-5