Changes in the fraction metabolized in children younger than four years: when is clearance scaling for the dominant elimination route in adults appropriate?

Author(s):
Rongen, A. van; Grijseels, R.; Calvier, E.A.M.; Allegaert, K.; Knibbe, C.A.J. (0000-0001-9893-4415); Krekels, E.H.J. (0000-0001-6006-1567)
Published
2025
Publication type
Article / Letter to editor
CYPMaturationPhysiologically-based pharmacokineticsSULTUGT
Date issued
2025-10-14
Language
English
Publisher
Springer Science and Business Media LLC
Is part of
Pharmaceutical Research (2025), Vol. 42, p. 1691-1700
hdl
1887/4282841
doi
10.1007/s11095-025-03948-7