Exploring the versatility of human β-glucosidases and related glycosylated metabolites with novel chemical tools

Author(s):
Bannink, S.
Published
2025
Publication type
Doctoral Thesis

Abstract

Thesis focused on uncovering the underlying mechanisms of the lysosomal storage disorders Gaucher's disease using chemical tools, biochemical assays and lipidomics.

Gaucher DiseaseLysosomal storage disorderLipidomicsChemical synthesis
Defense date
2025-10-24
Language
English
Supervisor(s)
Aerts, J.M.F.G.
Advisor(s)
Artola Perez de Azanza, M.E.
Committee member(s)
Ubbink, M.; Codée, J.D.C.; Overkleeft, H.S.; Stelt, M. van der; Lefeber, D.J.; Harms, A.C.; Marques, A.R.A.
Qualification
Ph.D.
Degree granting institution
Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University, Leiden
hdl
1887/4281749