Leukocytes at the maternal-fetal interface in human pregnancy

Author(s):
Sindram-Trujillo, A.P.
Published
2006
Publication type
Doctoral Thesis

Abstract

The aim of this thesis was to gain a

better understanding of the immunoregulatory mechanisms associated with

maternal tolerance of the fetus during pregnancy. The distribution of

decidual leukocytes, specifically uterine NK cells and T cells, in the decidua basalis and parietalis were studied in the setting of normal term pregnancy, following elective cesarean section or spontaneous vaginal delivery, in the setting of complicated pregnancy, and in the setting of assisted reproduction, and to study the function of term decidual leukocytes, specifically proliferation and cytokine production, in response to fetal and allogeneic blood leukocytes. Techniques involving flow cytometry, immunohistochemistry and mixed lymphocyte cultures were used to perform these studies.

Reproductive immunologyParadox of pregnancyDecidua parietalisDecidua basalisUterine NK cellsMaternal leukocytes
Defense date
2006-01-24
Language
English
Supervisor(s)
Claas, F.H.J.; Kanhai, H.H.H.
Advisor(s)
Roelen, D.L.; Scherjon, S.A.
Qualification
Ph.D.
Degree granting institution
Departments of Immunohematology and Blood Transfusion and of Obstetrics,, Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/4270
ISBN(s)
9090199756

Juridical information

Court
LEI Universiteit Leiden

Funding

Sponsorship
Stichting Fetal Maternal Research J.E.Jurriaanse Stichting Dr. Ir. van de Laar Stichting Medical Dynamics Wyeth Pharmaceuticals Novartis Pharma Innogenetics DiaMed Benelux