The repercussions of recognition: imprints of T cells on the tumor microenvironment

Slagter, M. (2025)

Doctoral Thesis

This thesis delves into the ways that T cells interact with the tumor microenvironment, the types of tumors that they can be expected to see as immunologically foreign, whether such antigen-recognition detectably leads to the specific destruction of antigen-carrying cells and how to enhance T cell activity to treat cancer patients, specifically those with triple negative breast cancer.

• Bioinformatics
• Computational biology
• Immunology
• T cells
• Cancer genomics
• Cancer immunology
• Immune oncology

• All authors: Slagter, M.
• Supervisor: Schumacher, T.N.M.; Wessels, L.F.A.
• Committee: Boer, R. de; Borghans, J.; Kok, M.; Mahfouz, A.; Visser, K.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2025-09-23
• ISBN (print): 9789464964516