Exploring the role of genetic complexity in pharmacogenomics

Author(s):
Zhai, Q.
Published
2025
Publication type
Doctoral Thesis

Abstract

The research presented in this dissertation investigates the causes of unexplained variability in drug exposure beyond the influence of common variants with a large effect-size. In this thesis, new approaches were applied to investigate the unexplained genetic variability.

Personalized therapeuticsPharmacogenomicsMedical genomicsLong-read sequencingCYP enzymesGenome-wide association studyFluoropyrimidines
Defense date
2025-09-04
Language
English
Supervisor(s)
Gelder, T. van; Swen, J.J.
Advisor(s)
Lee, M. van der
Committee member(s)
Heijmans, B.T.; Uitterlinden, A.G.; Asperen, C.J. van; Roon-Mom, W.M.C. van; Manson, M.L.
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/4259731
ISBN(s)
9789465107615