Leiden University Scholarly Publications

Persistent URL of this record https://hdl.handle.net/1887/4257582

Documents

In Collections

This item can be found in the following collections:

Colic, L.; Villa, L. M.; Dauvermann, M. R.; van Velzen, L. S.; Sankar, A.; Goldman, D. A.; ... ; Blumberg, H. P. (2022)

Brain grey and white matter structural associations with future suicidal ideation and behaviors in adolescent and young adult females with mood disorders

Article / Letter to editor
BACKGROUND\nMETHODS\nRESULTS\nCONCLUSIONS\nTo reduce suicide in females with mood disorders, it is critical to understand brain substrates underlying their vulnerability to future suicidal ideation and behaviors (SIBs) in adolescence and young adulthood. In an international collaboration, grey and white matter structure was investigated in adolescent and young adult females with future suicidal behaviors (fSB) and ideation (fSI), and without SIBs (fnonSIB).\nStructural (n = 91) and diffusion-weighted (n = 88) magnetic resonance imaging scans at baseline and SIB measures at follow-up on average two years later (standard deviation, SD = 1 year) were assessed in 92 females [age(SD) = 16.1(2.6) years] with bipolar disorder (BD, 28.3%) or major depressive disorder (MDD, 71.7%). One-way analyses of covariance comparing baseline regional grey matter cortical surface area, thickness, subcortical grey volumes, or white matter tensor-based fractional...Show moreBACKGROUND\nMETHODS\nRESULTS\nCONCLUSIONS\nTo reduce suicide in females with mood disorders, it is critical to understand brain substrates underlying their vulnerability to future suicidal ideation and behaviors (SIBs) in adolescence and young adulthood. In an international collaboration, grey and white matter structure was investigated in adolescent and young adult females with future suicidal behaviors (fSB) and ideation (fSI), and without SIBs (fnonSIB).\nStructural (n = 91) and diffusion-weighted (n = 88) magnetic resonance imaging scans at baseline and SIB measures at follow-up on average two years later (standard deviation, SD = 1 year) were assessed in 92 females [age(SD) = 16.1(2.6) years] with bipolar disorder (BD, 28.3%) or major depressive disorder (MDD, 71.7%). One-way analyses of covariance comparing baseline regional grey matter cortical surface area, thickness, subcortical grey volumes, or white matter tensor-based fractional anisotropy across fSB (n = 40, 43.5%), fSI (n = 33, 35.9%) and fnonSIB (n = 19, 20.6%) groups were followed by pairwise comparisons in significant regions (p < 0.05).\nCompared to fnonSIBs, fSIs and fSBs showed significant decreases in cortical thickness of right inferior frontal gyrus pars orbitalis and middle temporal gyrus, fSIs of left inferior frontal gyrus, pars orbitalis. FSIs and fSBs showed lower fractional anisotropy in left uncinate fasciculus and corona radiata, and fSBs in right uncinate and superior fronto-occipital fasciculi.\nThe study provides preliminary evidence of grey and white matter alterations in brain regions subserving emotional and behavioral regulation and perceptual processing in adolescent and young adult females with mood disorders with, versus without, future SIBs. Findings suggest potential targets to prevent SIBs in female adolescents and young adults.Show less
All authors
Colic, L.; Villa, L. M.; Dauvermann, M. R.; van Velzen, L. S.; Sankar, A.; Goldman, D. A.; Panchal, P.; Kim, J. A.; Quatrano, S.; Spencer, L.; Constable, R. T.; Suckling, J.; Goodyer, I. M.; Schmaal, L.; Harmelen, A. van; Blumberg, H. P.
Date
2022-11-21
Journal
JCPP Advances
Volume
2
Issue
4
DOI
doi:10.1002/jcv2.12118