Exploratory analysis of the effect of helminth infection on the immunogenicity and efficacy of the asexual blood-stage malaria vaccine candidate GMZ2

Author(s):
Nouatin, O.; Mengue, J.B.; Dejon-Agobé, J.C.; Fendel, R.; Ibáñez, J.; Ngoa, U.A.; Edoa, J.R.; Adégbité, B.R.; Honkpéhédji, Y.J.; Zinsou, J.F.; Hounkpatin, A.B.; Moutairou, K.; Homoet, A.; Esen, M.; Kreidenweiss, A.; Hoffman, S.L.; Theisen, M.; Luty, A.J.F.; Lell, B.; Agnandji, S.T.; Mombo-Ngoma, G.; Ramharter, M.; Kremsner, P.; Mordmüller, B.; Adegnika, A.A.
Published
2021
Publication type
Article / Letter to editor

Abstract

Helminths can modulate the host immune response to Plasmodium falciparum and can therefore affect the risk of clinical malaria. We assessed here the effect of helminth infections on both the immunogenicity and efficacy of the GMZ2 malaria vaccine candidate, a recombinant protein consisting of conserved domains of GLURP and MSP3, two asexual blood-stage antigens of P. falciparum. Controlled human malaria infection (CHMI) was used to assess the efficacy of the vaccine.

Date issued
2021-06-30
Language
English
Publisher
PLOS
Is part of
PLoS Neglected Tropical Diseases (2021), No. 6
hdl
1887/4253653
doi
10.1371/journal.pntd.0009361
URL
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0009361