Multimodality imaging in bone and soft tissue tumours: deciphering quantitative data

Abstract

Biological complexity and rarity of bone and soft tissue tumours complicate research on the use of medical imaging in these lesions. As a result, clinical implementation of quantitative imaging-based stratification models is lagging behind with research findings, hindering improvement in patient outcomes.

This thesis explores the potential of multimodality imaging to characterise tissue in a multitude of bone and soft tissue tumour subtypes, with an emphasis on response monitoring. Efforts are made to improve methodological aspects of radiological research that are especially relevant in sarcoma studies. A methodological pipeline is proposed to achieve spatial correlation of quantitative imaging with histological data, aiming to assist in deciphering the meaning of imaging features in sarcoma, as the Rosetta Stone aided in deciphering Egyptian hieroglyphs.