Design of branched swainsonines as selective Colgi alpha-mannosidase II inhibitors

Author(s):
Koemans, T.S.
Published
2025
Publication type
Doctoral Thesis

Abstract

Design and synthesis of two 3-substituted swainsonine derivatives with the aim to improve the potency and selectivity towards Golgi alpha-mannosidase II.

Swainsonine3-substituted swainsonineGolgi alpha-mannosidase IISynthesis of swainsonineSwainsonine derivatives
Defense date
2025-05-13
Language
English
Supervisor(s)
Overkleeft, H.S.; Codée, J.D.C.
Committee member(s)
Ubbink, M.; Aerts, J.M.F.G.; Davies, G.J.; Wrodnigg, T.M.; Armstrong, Z.W.B.; Artola Perez de Azanza, M.E.
Qualification
Ph.D.
Degree granting institution
Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University, Leiden
hdl
1887/4246015

Funding

Sponsorship
Netherlands Organisation for Scientific Research (NWO)