Two cases of intraocular undifferentiated pleomorphic sarcoma

Author(s):
Khatab, S.; Colijn, J.M.; Naus, N.; Verdijk, R.M. (0000-0003-1437-214X); Hötte, G.
Published
2024
Publication type
Article / Letter to editor

Abstract

Introduction: Undifferentiated pleomorphic sarcoma (UPS), formerly known as malignant fibrous histiocytoma, is a high-grade soft tissue sarcoma arising from mesenchymal stem cells. UPSs are rare and account for about 5% of all soft tissue sarcoma. UPSs arising in the head and neck are especially rare, comprising 1–3% of all UPSs.

Case Presentation: In this report, we describe 2 cases of intraocular UPS. Both cases concern 68-year-old males: one developing a UPS in an eviscerated socket after a chronic fibrinous inflammation and the other years after ocular trauma.

Conclusion: Our cases may support the hypothesis of chronic inflammation playing a role in sarcoma formation as they are characterized by a longstanding history of (surgical) trauma with signs of chronic inflammation and phthisis bulbi.

Adult ocular oncologyAdult ocular tumoursIntraocular tumoursOcular oncologyOrbital tumourSarcoma
Date issued
2024-12-31
Language
English
Is part of
Ocular Oncology and Pathology (2024), Vol. 10, no. 4, p. 227-233
hdl
1887/4239182
doi
10.1159/000541063
URL
https://karger.com/oop/article/10/4/227/913809/Two-Cases-of-Intraocular-Undifferentiated