Reliability of in vitro data for the mechanistic prediction of brain extracellular fluid pharmacokinetics of P-glycoprotein substrates in vivo; are we scaling correctly?

Author(s):
Valkengoed, D.W. van (0009-0006-7830-2553); Hirasawa, M.; Rottschäfer, V. (0000-0002-4150-3486); Lange, E.C.M. de (0000-0001-8303-1117)
Published
2025
Publication type
Article / Letter to editor
Date issued
2025-02-08
Language
English
Publisher
Springer Science and Business Media LLC
Is part of
Journal of Pharmacokinetics and Pharmacodynamics (2025), 16
hdl
1887/4210928
doi
10.1007/s10928-025-09963-w

Funding

Sponsorship
Horizon 2020(H2020)
Grant number
848068