Management of indeterminate thyroid nodules: changing the paradigm

Author(s):
Koster, E.J. de (0000-0001-8111-1172)
Published
2025
Publication type
Doctoral Thesis

Abstract

In this thesis, we showed that the diagnostic workup of cytologically indeterminate thyroid nodules can be improved by using FDG-PET/CT, which may accurately reduce the rate of futile diagnostic thyroid surgery by 40%. This thesis demonstrated that this diagnostic strategy is cost-effective, while maintaining quality of life. This was investigated through the EfFECTS trial, a Dutch multicentre randomized controlled trial.

Besides that, this thesis demonstrated that molecular diagnostics are also accurate and competitive with FDG-PET/CT.

ThyroidThyroid nodulesThyroid cancerNuclear imagingMolecular diagnosticsDiagnostics
Defense date
2025-03-06
Language
English
Supervisor(s)
Geus-Oei, L.F. de; Oyen, W.J.G.
Advisor(s)
Vriens, D.
Committee member(s)
Appelman-Dijkstra, N.M.; Vriens, M.R.; Comans, E.F.I.; Oosterhuis, J.W.A.; Tuin, K. van der
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/4196714
doi
10.60602/1887-4196714
ISBN(s)
9789465068497

Funding

Sponsorship
The EfFECTS trial was sponsored by a research grant from the Dutch Cancer Society (KWF).