Synthesis of D-alanylated wall teichoic acids from staphylococcus aureus

Author(s):
Voskuilen, T.
Published
2025
Publication type
Doctoral Thesis

Abstract

This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners. To this end, well-defined RboP are synthesised using new and established organic methodologies.

Staphylococcus aureusWall teichoic acidsPhosphoramidite chemistry
Defense date
2025-03-06
Language
English
Supervisor(s)
Codée, J.D.C.; Marel, G.A. van der
Committee member(s)
Ubbink, M.; Filippov, D.V.; Overkleeft, H.S.; Lay, L.; Willems, L.I.
Qualification
Ph.D.
Degree granting institution
Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University, Leiden
hdl
1887/4196685