Deciphering the Ubiquitin CODE by chemical tools

Author(s):
Perez Berrocal, D.A.
Published
2025
Publication type
Doctoral Thesis

Abstract

The scope of this PhD dissertation encompasses the study of Ub CODE signaling and druggability of E3 ligases by in-house developed chemical tools, aiming at its deciphering and modulation.

Ubiquitin Proteasome SystemE3 LigaseAssay reagentAssay developmentCovalent inhibitorHigh-Throughput screeningSolid-Phase Peptide SynthesisProteomicsHybrid chains
Defense date
2025-02-19
Language
English
Supervisor(s)
Vertegaal, A.C.O.; Ovaa, H.
Advisor(s)
Mulder, M.P.C.
Committee member(s)
Dijke, P. ten; Heitman, L; Baker, D.A.; Sixma, T.; Stelt, M. van der
Qualification
Ph.D.
Degree granting institution
Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/4195494
ISBN(s)
9789464963168

Funding

Sponsorship
The research presented in this thesis was performed at the Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands. The research was supported by the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 765445.