Paired CRISPR screening libraries for studying the function of the non-coding genome at scale

Author(s):
Pang, B.X.
Published
2024
Publication type
Article / Letter to editor

Abstract

The majority of the human non-coding genome remains poorly studied. A user-friendly genome-wide screening system composed of thousands of paired single-guide RNAs for the deletion of non-coding regions revealed key functions of many non-coding elements in cell growth and cell differentiation and in cellular response to drugs.

Date issued
2024-07-31
Language
English
Is part of
Nature Biomedical Engineering (2024), Vol. 8, no. 7, p. 806-807
hdl
1887/4175342
doi
10.1038/s41551-024-01215-5
URL
https://www.nature.com/articles/s41551-024-01215-5