One size does not fit all: towards personalised management of ductal carcinoma in situ

Author(s):
Schmitz, R.S.J.M.
Published
2024
Publication type
Doctoral Thesis

Abstract

Ductal carcinoma is a potential precursor of invasive breast cancer. There is a growing concern for overtreatment in women with DCIS. To reduce overtreatment, one needs accurate prediction of which lesions are at risk of progressing to invasive breast cancer. In this thesis we aimed to lay the groundwork for a novel prediction model and decision aid to support potential de-escalation of treatment in women with DCIS.

DCISDuctal carcinoma in situBreast cancer
Defense date
2024-12-18
Language
English
Supervisor(s)
Wesseling, J.; Schmidt, M.K.E.
Advisor(s)
Lips, E.H.
Committee member(s)
Smit, C.T.H.B.M.; Portielje, J.E.A.; Smidt, M.L.; Gils, C.H. van
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/4172675
ISBN(s)
9789465064789

Funding

Sponsorship
The research was funded by the PRECISION initiative, a recipient of a Cancer Grand Challenge award in 2017, jointly funded by Cancer Research UK and the Dutch Cancer Society (KWF) grant number C38317/A24043. The LORD-trial was supported by KWF, grant numbers NKI 2014- 7167; KWF NKI 2021-15093, and The Pink Ribbon Foundation, grant number: 2014-183 WO 54 PR130027.