Exploring liposome-targeted chemotherapy combined with immunotherapy in cancer

Abstract

In this thesis, we aim at two aspects of leveraging liposomal formulations to enhance the efficacy of cancer chemotherapy and immunotherapy. Firstly, we employed liposomes to deliver multiple regiments simultaneously or subsequently to the target site, which successfully achieved a precise tumor control with a synergistic or addictive effects between chemotherapy and immunotherapy. Secondly, the liposomal formulation can reduce the severe side effects induced by either chemotherapy or/and immunotherapy while remaining pronounced immunomodulation on both the local and systemic immune system.