Antibody-mediated delivery of viral epitopes to redirect virus-specific CD8+T cells to cancer cells

Author(s):
Wulp, W. van der
Published
2024
Publication type
Doctoral Thesis

Abstract

Therapeutic antibody-epitope conjugates (AECs) are promising new therapeutic modalities to deliver virus-specific T-cell epitopes to cancer cells, and thereby redirecting virus-specific T cells to attack tumor cells. The research described in this thesis aimed to develop, optimize, and discover the therapeutic potential of AECs, and to evaluate whether the concept could be broadened.

Antibody-epitope conjugatesVirus-specific T cellsRedirection of T cellsAntibody conjugation strategiesBispecific antibodies
Defense date
2024-11-14
Language
English
Supervisor(s)
Hoeben, R.C.; Heemskerk, M.H.M.
Advisor(s)
Ressing, M.E.
Committee member(s)
Trouw, L.A.; Griffioen, M.; Egmond, M. van; Leusen, J.H.W.
Qualification
Ph.D.
Degree granting institution
Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/4108803
ISBN(s)
9789465064123