Leiden University Scholarly Publications

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Chen, Y. (2024)

Squaramide-based interpenetrated networks for load-bearing applications

Doctoral Thesis
This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture. We first examined how the hydrophilic-hydrophobic balance and hydrogen bonds in tripodal squaramide monomers influence polymer properties. Then we presented a cartilage-like double-network (DN) hydrogel that supports chondrocyte growth and ECM production. Following this, a phenol-crosslinked DN hydrogel with cartilage-mimicking properties was developed. Afterwards we incorporated gold nanoparticles (AuNPs) into DN hydrogels, improving mechanical properties and enabling a photo-thermal effect for cancer therapy. The final section summarizes findings and suggests future research on squaramide-based materials for 3D cell culture applications.
Squaramide
Hydrogel
Biological applications
All authors
Chen, Y.
Supervisor
Kros, A.; Kieltyka, R.E.
Committee
Ubbink, M.; Dame, R.T.; Voets, I.K.; Meulenbelt, I.; Jawerth, L.M.M.
Qualification
Doctor (dr.)
Awarding Institution
Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University
Date
2024-11-08
ISBN (print)
9789465064918