Leiden University Scholarly Publications

Persistent URL of this record https://hdl.handle.net/1887/4106838

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Bruin, D. de (2024)

Applications for DNA-encapsulated silver clusters in physics, biology and medicine

Doctoral Thesis
We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications. We analyze the structures as optical emitters, finding uses for them in biosensing, including performing measurements on live cell interiors, and analysis of DNA hybridization dynamics. Secondly, we use the metal to create short range interaction schemes for the purpose of measuring distances on the nanometer scale. Finally, we find applications for DNA-metal hybrids in therapeutics, introducing a novel method to kill cancer cells which shows a unique potential for precision treatments.
DNA
Metal clusters
Optics
Biosensing
Theragnostics
Oncology
All authors
Bruin, D. de
Supervisor
Bouwmeester, D.; Heinrich, D.
Committee
Dekker, N.; Vogel, W.; Huber, M.; Molen, S.J. van der; Schmidt, T.
Qualification
Doctor (dr.)
Awarding Institution
Leiden Institute of Physics (LION), Faculty of Science, Leiden University
Date
2024-10-29

Funding

Sponsorship
Sponsors This work was supported by the Netherlands Organization for Scientific Research (NWO/OCW), including through the Spinoza Prize 2014, and was funded in collaboration with the Fraunhofer ISC and Fraunhofer IME, Germany.