The fine line between sleep and wakefulness: understanding hypersomnolence disorders and sleep in the intensive care environment

Abstract

This thesis explores two distinct scenarios in which sleep disturbances occur: in the context of central disorders of hypersomnolence (Part I), including narcolepsy type 1, type 2 and idiopathic hypersomnia, and in the critical care environment (Part II).

Although the causes of disrupted sleep differ in these two settings, the resulting sleep patterns exhibit similar and overlapping characteristics. Enhancing our understanding of sleep-related aspects in one domain could enhance our understanding of sleep in the other domain as well.

The outcomes of studies explored in this thesis underscore the opportunities in both fields. The necessity for refining diagnostic criteria and assessment methods is highlighted as well. By pinpointing areas for future investigation, this thesis sets the stage for more precise diagnostic tools and a deeper understanding of the intricate relationship between sleep and overall well-being, with the ultimate goal of better prevention or treatment and thus better (patient) care.