Design, synthesis and application of sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases

Author(s):
Kok, K.
Published
2024
Publication type
Doctoral Thesis

Abstract

This thesis describes the design and synthesis of novel small molecules based on sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases related to Fabry and Pompe disease.

FabryPompeSulfamidateSulfoximineA4GALTglycosyltransferaseUDP-sugarPSI-reagent
Defense date
2024-10-02
Language
English
Supervisor(s)
Overkleeft, H.S.; Artola Perez de Azanza, M.E.
Committee member(s)
Ubbink, M.; Codée, J.D.C.; Kasteren, S.I. van; Stelt, M. van der; Walvoort, M.T.C.; Helden van Noort, G. van der
Qualification
Ph.D.
Degree granting institution
Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University, Leiden
hdl
1887/4093669