Leiden University Scholarly Publications

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Kok, K. (2024)

Design, synthesis and application of sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases

Doctoral Thesis
This thesis describes the design and synthesis of novel small molecules based on sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases related to Fabry and Pompe disease.
Fabry
Pompe
Sulfamidate
Sulfoximine
A4GALT
glycosyltransferase
UDP-sugar
PSI-reagent
All authors
Kok, K.
Supervisor
Overkleeft, H.S.; Artola Perez de Azanza, M.E.
Committee
Ubbink, M.; Codée, J.D.C.; Kasteren, S.I. van; Stelt, M. van der; Walvoort, M.T.C.; Helden van Noort, G. van der
Qualification
Doctor (dr.)
Awarding Institution
Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University
Date
2024-10-02