Schistosoma mansoni extracellular vesicles and their impact on the immune system: glycosylated messengers in host-pathogen communication

Kuipers, M.E. (2024)

Doctoral Thesis

The research in this thesis explores the interaction between the parasitic worm Schistosoma mansoni and the immune system. The co-evolution of these worms with the human host has enabled them to develop optimal strategies to influence the immune system. The studies presented focus on extracellular vesicles (EVs) released by the worms and the role of glycans (sugar molecules) in this interaction. Both adult worm and larval EVs contain glycans and have different effects on immune cells, such as B-lymphocytes and dendritic cells, stimulating the release of signaling molecules. The glycans on the EVs appear to be crucial for interacting with specific receptors on immune cells. This research contributes to understanding the communication between parasites and their hosts and could potentially lead to the development of new therapies for immune-related diseases.

• Extracellular vesicles
• Schistosoma mansoni
• Glycans
• Glycosylation
• Host-pathogen interaction
• Immune responses
• Helminths
• Parasites
• C-type lectin receptors

• All authors: Kuipers, M.E.
• Supervisor: Hokke, C.H.; Smits, H.H.
• Co-supervisor: Nolte-'t Hoen, E.N.M.
• Committee: Goumans, M.J.T.H.; Ottenhoff, T.H.M.; Veen, A.G.van der; Boons, G.J.P.H.; Hoffmann, K.R.
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden University Medical Center (LUMC), Leiden University
• Date: 2024-09-25
• ISBN (print): 9789465062877